Special compounded creams-lotions-roll ons can be used to treat mild underarm sweating. They contain a chemical known as Glycopyrrolate. The concentration can be tailor made for your skin sensitivities.

Facts on compounded creams for sweaty underarms

  • Specialist at Sweat Free can prescribe specially formulated creams
  • The concentration of anti-sweat agents can be tailored for each patient
  • Anti-sweat medications can be placed in a lotion, cream, roll on or lotion base
  • The chemical is known as an anti-cholinergic and work by decreasing the activation of nerves which cause you to sweat
  • Compounded solutions are best applied at night and washed off several hours later
  • Compounded solutions can only be made up by special pharmacies, and you will require a prescription by either a GP or Specialist
  • Occasionally we combine compounded creams after your first treatment with miraDry to help reduce sweating whilst waiting for your second treatment

How do special formulated chemicals decrease underarm sweating?

Formulated anti-sweating creams contain anti-cholinergic properties. In summary, this family of drugs block the production of sweat by the sweat gland. The chemical we use is called glycopyrrolate, and the concentration varies between 0.5 to 3%.

What bases can we formulate the anti-sweating chemicals in?

Our specialists prescribe a variety of bases including creams, lotions, sprays and roll ons to help decrease mild cases of underarm sweating that do not respond to over the counter antiperspirants such as Driclor or Rexona Sport.

What are the side effects of compounded solutions for underarm sweating?

Anti-sweating creams, such as compounded glycopyrrolate are usually well tolerated, and adverse reactions are uncommon.

Side effects include:

  1. Skin irritation: Such as redness and excessive dryness
  2. Systemic Absorption means the chemical gets absorbed through the skin, leading to drug in the blood stream. This may cause dry mouth, sedation (feeling tired), and blurred vision.

Side effects are usually concentration related. The trick is to find a concentration that will deliver the results, at a certain concentration, whilst eliminating adverse effects.  

What is the best application method of applying underarm anti-sweating chemicals?

Glycopyrrolate solutions can be used up to 2-3 times a day, but we advise all patients to start once at night. It is best applied to dry, clean skin.

Patients can leave on over night, before washing off in the morning. If you do not experience any side effects creams can be increased to 2-3 times a day.

Remember, cream are only useful for mild cases of excessive underarm sweating.

Which pharmacy stocks formulated anti-sweating prescriptions?

compounding pharmacy

Glycopyrrolate prescriptions are highly specialised in their formulation, in addition most patients will require a customised concentration to obtain the best results, whist minimising side effects. Special pharmacies known as COMPOUNDING pharmacies can help formulate anti-sweating formulatinos

We recommend My Skin Pharmacy, in Brisbane to help you with your prescription.

Ph: (07) 3039 15 89

How much do anti-sweating underarm prescriptions cost?

This will vary on the type and concentration we use. MY SKIN PHARMACY charges between $40 - $110 per container. This depends on the amount and concentration of glycopyrrolate need to stop your underarm sweating.

Remember - this treatment should only be considered if over the counter antiperspirants don't work, and only if your sweating is MILD.

What other treatment options are there for excessive underarm sweating?

Creams, lotions, and roll ons including brands such as Rexona, Dove Clinical, Driclor, and even compounded Glycopyrrolate are only useful in mild cases of axillary hyperhidrosis / underarm sweating. They do not work if your sweating is severe.

Other treatment options include -

Sweat stopping treatments injections

This treatment is effective in up to 95% of cases and can stop excessive underarm sweating for up to 6 months. This procedure involves multiple small injections into the area of maximal sweating and takes only a few minutes to perform.

The procedure is not permanent and will need to be repeated according to your sweat pattern. Most patients require 3 injection sessions per year to remain sweat free. Sweat stopping treatments for underarm sweating is covered under Medicare and PBS.

More on sweat stopping treatments injections for sweating

Anti sweating tablets

Can be used to decrease sweating. They can be useful for generalised sweating, but may help localised areas such as sweaty underarms, as well as hands and feet. Most commonly used tablet is Propantheline Bromide. Tablets for sweating can be obtained by a GP thru a prescription.

More on Tablets for sweating


Ideal for cases of moderate to severe underarm sweating. Two treatments 3 months apart will reduce sweating by 80-90% - for life. No more sweat stopping treatments injections, and no more creams. Consider miradry as a permanent solution for moderate to severe cases of axillary hyperhidrosis.

Specialist perspective on compounded solutions for sweaty underarms


Dr Davin S. Lim
Specialist Dermatologist
Sweat Free Clinics

The use of formulated anti-sweating creams can be useful for cases of mild sweating. Glycopyrrolate in creams, roll-ons, lotions and sprays can be used to treat underarm sweating, as well as sweaty hands, feet and facial areas. The concentration can be adjusted by the nurse or specialist according to how the patient responds. When do we consider the use of compounded solutions? The answer is if sweating is mild and if over the counter antiperspirants such as Dove, Rexona, and Driclor do not work. For cases of moderate to severe sweating, sweat stopping treatments or miradry is the answer. Sweat stopping treatments are temporary, miradry is permanent.

Occasionally we combine miraDry with compounded creams, especially between treatment one and two, to give the patient relief between treatments.